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Achaete-scute complex
The ''achaete-scute'' complex (''AS-C'') is a group of four genes (''achaete'', ''scute'', ''lethal of scute'', and ''asense'') in the fruit fly ''Drosophila melanogaster''. These genes encode basic helix-loop-helix transcription factors that have been best studied in their regulation of nervous system development.〔(【引用サイトリンク】url=http://www.sdbonline.org/fly/aignfam/neuropro.htm#dafka1 )〕 Because of their role in specifying neuroblast fate, the genes of the ''AS-C'' are called proneural genes. However, the ''AS-C'' has non-proneural functions, such as specifying muscle and gut progenitors.〔 Homologues of ''AS-C'' in other animals, including humans and other vertebrates, have similar functions.
Genes of the ''AS-C'' interact with the Notch pathway in both their proneural functions as well as their specification of gut and muscle cells.〔
==Genetic structure==
The complex is found near the tip of the X chromosome, just 3' of ''yellow'', in chromosome bands 1A6 through 1B3. It occupies around 93 kb of the genome, with all four genes oriented in the same direction.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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